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Production of 2-Hydroxyisobutyric Acid from Methanol by Methylobacterium extorquens AM1 Expressing (R)-3-Hydroxybutyryl Coenzyme A-Isomerizing Enzymes

Maria-Teresa Rohde, Sylvi Tischer, Hauke Harms, Thore Rohwerder

Appl Environ Microbiol. 2017 Feb 1; 83(3): e02622-16. Prepublished online 2016 Nov 11. Published online 2017 Jan 17. doi: 10.1128/AEM.02622-16

PMCID:: PMC5244315

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Biosynthesis of 2-hydroxyisobutyric acid (2-HIBA) from renewable carbon

Thore Rohwerder, Roland H Müller

Microb Cell Fact. 2010; 9: 13. Published online 2010 Feb 25. doi: 10.1186/1475-2859-9-13

PMCID:: PMC2847961

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Bacterial Acyl-CoA Mutase Specifically Catalyzes Coenzyme B₁₂-dependent Isomerization of 2-Hydroxyisobutyryl-CoA and (S)-3-Hydroxybutyryl-CoA

Nadya Yaneva, Judith Schuster, Franziska Schäfer, Vera Lede, Denise Przybylski, Torsten Paproth, Hauke Harms, Roland H. Müller, Thore Rohwerder

J Biol Chem. 2012 May 4; 287(19): 15502–15511. Published online 2012 Mar 20. doi: 10.1074/jbc.M111.314690

PMCID:: PMC3346121

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Structural Basis of the Stereospecificity of Bacterial B₁₂-dependent 2-Hydroxyisobutyryl-CoA Mutase

Nadya Kurteva-Yaneva, Michael Zahn, M.-Teresa Weichler, Robert Starke, Hauke Harms, Roland H. Müller, Norbert Sträter, Thore Rohwerder

J Biol Chem. 2015 Apr 10; 290(15): 9727–9737. Published online 2015 Feb 26. doi: 10.1074/jbc.M115.645689

PMCID:: PMC4392272

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Metabolism of 2-Methylpropene (Isobutylene) by the Aerobic Bacterium Mycobacterium sp. Strain ELW1

Samanthi Kottegoda, Elizabeth Waligora, Michael Hyman

Appl Environ Microbiol. 2015 Mar; 81(6): 1966–1976. Prepublished online 2015 Jan 9. Published online 2015 Feb 27. doi: 10.1128/AEM.03103-14

PMCID:: PMC4345374

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Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway

He Huang, Zhouqing Luo, Shankang Qi, Jing Huang, Peng Xu, Xiuxuan Wang, Li Gao, Fangyi Li, Jian Wang, Wenhui Zhao, Wei Gu, Zhucheng Chen, Lunzhi Dai, Junbiao Dai, Yingming Zhao

Cell Res. 2018 Jan; 28(1): 111–125. Published online 2017 Dec 1. doi: 10.1038/cr.2017.149

PMCID:: PMC5752845

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The Alkyl tert-Butyl Ether Intermediate 2-Hydroxyisobutyrate Is Degraded via a Novel Cobalamin-Dependent Mutase Pathway

Thore Rohwerder, Uta Breuer, Dirk Benndorf, Ute Lechner, Roland H. Müller

Appl Environ Microbiol. 2006 Jun; 72(6): 4128–4135. doi: 10.1128/AEM.00080-06

PMCID:: PMC1489616

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Quantitative Proteomics Reveals the Role of Lysine 2-Hydroxyisobutyrylation Pathway Mediated by Tip60

Ning Wang, Yue Jiang, Ping Peng, Guobin Liu, Shankang Qi, Kun Liu, Qi Mei, Jian Li

Oxid Med Cell Longev. 2022; 2022: 4571319. Published online 2022 Feb 8. doi: 10.1155/2022/4571319

PMCID:: PMC8847014

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Global Lysine Acetylation and 2-Hydroxyisobutyrylation Profiling Reveals the Metabolism Conversion Mechanism in Giardia lamblia

Wenhe Zhu, Xiaoming Jiang, Hongyu Sun, Yawei Li, Wenyan Shi, Meiyu Zheng, Di Liu, Aixin Ma, Xianmin Feng

Mol Cell Proteomics. 2021; 20: 100043. Published online 2021 Jan 7. doi: 10.1074/mcp.RA120.002353

PMCID:: PMC8724866

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The Undernourished Neonatal Mouse Metabolome Reveals Evidence of Liver and Biliary Dysfunction, Inflammation, and Oxidative Stress

Geoffrey A. Preidis, Mignon A. Keaton, Philippe M. Campeau, Brooke C. Bessard, Margaret E. Conner, Peter J. Hotez

J Nutr. 2014 Mar; 144(3): 273–281. Published online 2013 Dec 31. doi: 10.3945/jn.113.183731

PMCID:: PMC3927544

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p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

He Huang, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, Jason W. Locasale, Robert G. Roeder, Yingming Zhao, Xiaoling Li

Mol Cell. Author manuscript; available in PMC 2019 May 17.

Published in final edited form as: Mol Cell. 2018 May 17; 70(4): 663–678.e6. doi: 10.1016/j.molcel.2018.04.011

Correction in:: Mol Cell. 2018 Jun 7; 70(5): 984.

PMCID:: PMC6029451

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Proteome-wide identification of lysine 2-hydroxyisobutyrylation reveals conserved and novel histone modifications in Physcomitrella patens

Zhiming Yu, Jun Ni, Wei Sheng, Zhikun Wang, Yuhuan Wu

Sci Rep. 2017; 7: 15553. Published online 2017 Nov 14. doi: 10.1038/s41598-017-15854-z

PMCID:: PMC5686104

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Thermophilic Coenzyme B₁₂-Dependent Acyl Coenzyme A (CoA) Mutase from Kyrpidia tusciae DSM 2912 Preferentially Catalyzes Isomerization of (R)-3-Hydroxybutyryl-CoA and 2-Hydroxyisobutyryl-CoA

Maria-Teresa Weichler, Nadya Kurteva-Yaneva, Denise Przybylski, Judith Schuster, Roland H. Müller, Hauke Harms, Thore Rohwerder

Appl Environ Microbiol. 2015 Jul; 81(14): 4564–4572. Prepublished online 2015 Apr 24. Published online 2015 Jun 19. doi: 10.1128/AEM.00716-15

PMCID:: PMC4551191

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Actinobacterial Degradation of 2-Hydroxyisobutyric Acid Proceeds via Acetone and Formyl-CoA by Employing a Thiamine-Dependent Lyase Reaction

Thore Rohwerder, Maria-Teresa Rohde, Nico Jehmlich, Jessica Purswani

Front Microbiol. 2020; 11: 691. Published online 2020 Apr 15. doi: 10.3389/fmicb.2020.00691

PMCID:: PMC7176365

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2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans

Emily Schifano, Giorgia Conta, Adele Preziosi, Carino Ferrante, Giovanni Batignani, Patrizia Mancini, Alberta Tomassini, Fabio Sciubba, Tullio Scopigno, Daniela Uccelletti, Alfredo Miccheli

Front Mol Biosci. 2022; 9: 986022. Published online 2022 Nov 23. doi: 10.3389/fmolb.2022.986022

PMCID:: PMC9749906

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Development of an analytical method for accurate and precise determination of rare earth element concentrations in geological materials using an MC-ICP-MS and group separation

Seung-Gu Lee, Kyung-Seok Ko

Front Chem. 2022; 10: 906160. Published online 2023 Jan 12. doi: 10.3389/fchem.2022.906160

PMCID:: PMC9878377

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Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients

Henricus A. M. Mutsaers, Udo F. H. Engelke, Martijn J. G. Wilmer, Jack F. M. Wetzels, Ron A. Wevers, Lambertus P. van den Heuvel, Joost G. Hoenderop, Rosalinde Masereeuw

PLoS One. 2013; 8(8): e71199. Published online 2013 Aug 2. doi: 10.1371/journal.pone.0071199

PMCID:: PMC3732267

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¹H-NMR-based urine metabolomics of prostate cancer and benign prostatic hyperplasia

Mohammed Zniber, Tarja Lamminen, Pekka Taimen, Peter J. Boström, Tan-Phat Huynh

Heliyon. 2024 Apr 15; 10(7): e28949. Published online 2024 Mar 31. doi: 10.1016/j.heliyon.2024.e28949

PMCID:: PMC11015411

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Recent Approaches for Chemical Speciation and Analysis by Electrospray Ionization (ESI) Mass Spectrometry

Serena Indelicato, David Bongiorno, Leopoldo Ceraulo

Front Chem. 2020; 8: 625945. Published online 2021 Jan 20. doi: 10.3389/fchem.2020.625945

PMCID:: PMC7855954

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Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis

Jianglan Long, Zhirui Yang, Long Wang, Yumei Han, Cheng Peng, Can Yan, Dan Yan

BMC Endocr Disord. 2020; 20: 174. Published online 2020 Nov 23. doi: 10.1186/s12902-020-00653-x

PMCID:: PMC7685632

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Fig. 5

Metabolite profiling diagrams. a Metabolite profiling diagrams for metabolites in type 2 diabetes mellitus patients. b Metabolite profiling diagrams for metabolites in pre-diabetic patients. Abbreviations: OR, odds ratio; LPC, lysophosphatidylcholine; L-GPC, linoleoyl-glycerophospho-choline; α-HIB, α-hydroxyisobutyric acid; β-HB, β-hydroxybutyric acid; 4-MOP, 4-methyl-2-oxopentanoic acid; 3-MOP, 3-methyl-2-oxopentanoic acid; 3-MOB, 3-methyl-2-oxobutyric acid; α-KB, ketobutyric acid; β-HIB, β-hydroxyisobutyric acid

Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis

BMC Endocr Disord. 2020;20:174.
FIGURE 4

The relative abundance of metabolites with the highest VIP values in the serum of mice from the Sham group and 6, 36, 72, and 168 h after PHx. The box plot shows the relative abundance of metabolites, including ornithine (A), phenylalanine (B), 2-aminobutanoic acid (C), 2-hydroxybutyric acid (D), lysine (E), glutamic acid (F), ethanolamine (G), threonine (H), phosphoric acid (I), glucitol (J), myo-inositol (K) and alpha-hydroxyisobutyric acid (L). Data were represented as mean ± S.D.

Prediction of Liver Weight Recovery by an Integrated Metabolomics and Machine Learning Approach After 2/3 Partial Hepatectomy

Front Pharmacol. 2021;12:760474.
Fig. 1

Oxidation of MTBE to known vertebrate metabolites. In mammals, MTBE is oxidized by CYP 2A6 and 3A4 to TBA and formaldehyde (; ). Primary metabolites (bold faced) can be excreted or undergo further oxidation. The enzymes that oxidize TBA to 2-methyl-1,2-propanediol to α-hydroxyisobutyric acid are unknown. Formaldehyde is oxidized to methanol by alcohol dehydrogenase or to formic acid by aldehyde dehydrogenase. Based on and .

Methyl tert butyl ether targets developing vasculature in zebrafish (Danio rerio) embryos

Aquat Toxicol. ;105(0):29-40.
Figure 1

Typical ¹H NMR spectra of control human urine samples containing: (A) no borate; (B) expansion of the region between δ1.1–1.4 from A; (C) the same sample with added 30.73 mM borate; (D) expansion of the region between δ1.1–1.4 from C. Peaks annotated “1” and “2” correspond to α-hydroxyisobutyric acid and methylmalonic acid, respectively, either free (in A and B) or in complex with borate (in C and D).

Large scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: Investigation of borate preservation

Anal Chem. ;81(12):4847-4856.